Abstract
Stereoselective synthesis of new C-C bonds is one of the main objectives of organic chemistry. In this field, silyl activation of alkenes is a useful organic tool in a huge number of Lewis acid promoted reactions due to the ability of the silicon to stabilize neighboring cations. This review summarizes the Lewis acid promoted addition of silyl enol ethers and allylsilanes to epoxides and other small oxygenated rings, which has proved to be an efficient method of synthesis of asymmetric alcohols and other target compounds.
Keywords: Alcohol, allylsilane, allylsiloxane, biomimetic cyclization, bishomoallylic alcohol, lactone, oxetane, oxirane, γ-hydroxyketone, propargylsilane.
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Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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