MicroRNA-34a: Role in Cancer and Cardiovascular Disease

Title:MicroRNA-34a: Role in Cancer and Cardiovascular Disease

Volume: 15 Issue: 4

Author(s): Xi Chen, Jian-Ya Zhou and Jian-Ying Zhou

Affiliation:

Keywords: Cardiovascular diseases, microRNA-34a, molecular target therapy, neoplasms.

Abstract: Small non-coding microRNAs (miRNAs) regulate gene expression at the post-transcriptional and translational levels. The dysregulated miRNAs are involved in a large variety of diseases including cancer and cardiovascular diseases. MiR-34a is one of the most anti-oncomiRs that is down-regulated in multiple types of cancer. It regulates a wide range of genes and pathways involved in cancer initiation, progression and metastasis. Next to cancer, miR-34a is recently found to be implicated in cardiovascular disease as one damager factor. In this review, we highlight the complex roles of miR-34a in cancer and cardiovascular disease, as well as the therapeutic potentials.

Cite this article as:

Chen Xi, Zhou Jian-Ya and Zhou Jian-Ying, MicroRNA-34a: Role in Cancer and Cardiovascular Disease, Current Drug Targets 2014; 15 (4) . https://dx.doi.org/10.2174/1389450115666140120102935