Tritiated Opioid Receptor Ligands as Radiotracers

Title:Tritiated Opioid Receptor Ligands as Radiotracers

Volume: 19 Issue: 42

Author(s): Geza Toth and Jayapal Reddy Mallareddy

Affiliation:

Keywords: Radiotracers, tritium, opioid receptors, opiates, opioid peptides.

Abstract: Tritiated opioid ligands are essential tools for the identification of opioid receptors. This review deals with the syntheses of tritiated opioid peptide derivatives, including enkephalins, dynorphins, dermorphins, deltorphins and endomorphins, and also discusses tritium-labeled nonpeptide opioids. It additionally focuses on the relevance of tritium-labeled opioid compounds as research tools for investigating opioid receptor pharmacology. Agonists and antagonists are used for the characterization of new opioid ligands by means of radioreceptor binding assays. Further topics covered in this review are the distribution of the endogenous peptides in the central nervous system and peripheral tissues, and degradation studies of opioids in brain membrane preparations and the blood.

Cite this article as:

Toth Geza and Mallareddy Reddy Jayapal, Tritiated Opioid Receptor Ligands as Radiotracers, Current Pharmaceutical Design 2013; 19 (42) . https://dx.doi.org/10.2174/138161281942140105170259