Synthesis of Some New Flurbiprofen Analogues as Anti-inflammatory Agents

Title:Synthesis of Some New Flurbiprofen Analogues as Anti-inflammatory Agents

Volume: 13 Issue: 2

Author(s): Laxmikant H. Nitlikar, Jaiprakash N. Sangshetti and Devanand B. Shinde

Affiliation:

Keywords: Azoles, α-Aryl propionic acid, non-steroidal anti-inflammatory drugs, rat paw edema, suzuki cross-coupling reaction.

Abstract: A series of new α-aryl propionic acid derivatives had been synthesized through different synthetic routes from the readily available 2-fluoronitrobenzene as key starter. The synthesized compounds were screened for their antiinflammatory activity using rat paw edema method. Azoles (6c, 6h and 6i) have showed considerable good antiinflammatory activity. The present series with some modification may serve as important core for the development of new anti-inflammatory agents.

Cite this article as:

Nitlikar H. Laxmikant, Sangshetti N. Jaiprakash and Shinde B. Devanand, Synthesis of Some New Flurbiprofen Analogues as Anti-inflammatory Agents, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2014; 13 (2) . https://dx.doi.org/10.2174/1871523012666131224110834