Wells-Dawson Type Catalyst: An Efficient, Recoverable and Reusable Solid Acid Catalyst for the Solvent-Free Synthesis of Benzodiazepines

Title:Wells-Dawson Type Catalyst: An Efficient, Recoverable and Reusable Solid Acid Catalyst for the Solvent-Free Synthesis of Benzodiazepines

Volume: 3 Issue: 2

Author(s): Gustavo A. Pasquale, Diego M. Ruiz, Graciela T. Baronetti, Horacio J. Thomas, Juan C. Autino and Gustavo P. Romanelli

Affiliation:

Keywords: Benzodiazepines, Green chemistry, Heterogeneous catalysis, Heteropolyacid, Solvent-free reaction, Wells-Dawson structure.

Abstract: Various 3-H-1,5-benzodiazepines were prepared from the solvent-free reaction of o-phenylenediamine and substituted 1,3-diphenyl-1,3-propanedione, giving good yields of benzodiazepines. The H₆P₂W₁₈O₆₂.24H₂O solid heteropolyacid, which possesses a Wells-Dawson type structure was used as catalyst both in bulk and silica-supported forms (0.1, 0.2, 0.4 and 0.6 g/g, named 0.1WDSiO₂, 0.2WDSiO₂, 0.4WDSiO₂ and 0.6WDSiO₂, respectively). The structure of the synthesized heteropolyacid was confirmed using different characterization techniques (FTIR; ³¹P-RMN, and potentiometric titration).

Cite this article as:

Pasquale A. Gustavo, Ruiz M. Diego, Baronetti T. Graciela, Thomas J. Horacio, Autino C. Juan and Romanelli P. Gustavo, Wells-Dawson Type Catalyst: An Efficient, Recoverable and Reusable Solid Acid Catalyst for the Solvent-Free Synthesis of Benzodiazepines, Current Catalysis 2014; 3 (2) . https://dx.doi.org/10.2174/2211544702666131224003128