Naturally Occurring Methyl Salicylate Glycosides

Title:Naturally Occurring Methyl Salicylate Glycosides

Volume: 14 Issue: 1

Author(s): Ping Mao, Zizhen Liu, Meng Xie, Rui Jiang, Weirui Liu, Xiaohong Wang, Shen Meng and Gaimei She

Affiliation:

Keywords: Analgesic, anti-inflammation, antipyretic, methyl salicylate glycoside, NSAIDs.

Abstract: As an important part of non steroids anti-inflammation drug (NSAIDs), salicylate has developed from natural substance salicylic acid to natrium salicylicum, to aspirin. Now, methyl salicylate glycoside, a new derivative of salicylic acid, is modified with a -COOH group integrated one methyl radical into formic ether, and a -OH linked with a monosaccharide, a disaccharide or a trisaccharide unit by glycosidic linkage. It has the similar pharmacological activities, anti-inflammatory, analgesic, antipyretic and antithrombotic as the previous salicylates’ without resulting in serious side effects, particularly the gastrointestinal toxicity. Owing to the superiority of those significant bioactivities, methyl salicylate glycosides have became a hot research area in NSAIDs for several years. This paper compiles all 9 naturally occurring methyl salicylate glycosides, their distribution of the resource and pharmacological mechanism, which could contribute to the new drug discovery.

Cite this article as:

Mao Ping, Liu Zizhen, Xie Meng, Jiang Rui, Liu Weirui, Wang Xiaohong, Meng Shen and She Gaimei, Naturally Occurring Methyl Salicylate Glycosides, Mini-Reviews in Medicinal Chemistry 2014; 14 (1) . https://dx.doi.org/10.2174/1389557513666131211110004