GARM: Genome Assembly, Reconciliation and Merging Pipeline

Title:GARM: Genome Assembly, Reconciliation and Merging Pipeline

Volume: 14 Issue: 3

Author(s): Luz Mayela Soto-Jimenez, Karel Estrada and Alejandro Sanchez-Flores

Affiliation:

Keywords: Bioinformatics, genome assembly, genome reconciliation, genome merging, meta-assembly, next-generation sequencing.

Abstract: Over the past decades DNA sequencing technologies have been improving in aspects like quality, read length, runtimes and yields, all at a lower cost. Despite these improvements, genome assembly remains a challenge in genome sequencing projects, especially when different sequencing platforms are used. At the present, there is no program that can handle and assemble different sequencing technologies better than specialized software for each of them. Also, very few protocols are available for merging results from different algorithms, technologies or both. We present GARM, (Genome Assembler, Reconciliation and Merging) a pipeline to merge assemblies from different algorithms or sequencing technologies.

Cite this article as:

Soto-Jimenez Mayela Luz, Estrada Karel and Sanchez-Flores Alejandro, GARM: Genome Assembly, Reconciliation and Merging Pipeline, Current Topics in Medicinal Chemistry 2014; 14 (3) . https://dx.doi.org/10.2174/1568026613666131204110628