Three-Component Synthesis of Spiro[Indoline-3,4'-Pyrano[3,2-b]Pyran]- 2,8'-Diones Using a One-Pot Reaction

Abbas      Rahmati; Zahra      Khalesi; Tahmineh      Kenarkoohi

doi:10.2174/13862073113166660067

Abstract

A one-pot, three-component reaction of an isatin and kojic acid with an active methylene compound such as ethyl cyanoacetate, methyl cyanoacetate and malononitrile in methanol using catalytic amount of DABCO to give 2'- amino-6'-(hydroxymethyl)-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-2,8'-diones in good to excellent yields under reflux conditions, is described.

Keywords: Isatin, kojic acid, malononitrile, multi-component reaction, pyrano[3, 2-b]pyranone, pyranopyranone.

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Combinatorial Chemistry & High Throughput Screening

Title:Three-Component Synthesis of Spiro[Indoline-3,4'-Pyrano[3,2-b]Pyran]- 2,8'-Diones Using a One-Pot Reaction

Volume: 17 Issue: 2

Author(s): Abbas Rahmati, Zahra Khalesi and Tahmineh Kenarkoohi

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Keywords: Isatin, kojic acid, malononitrile, multi-component reaction, pyrano[3, 2-b]pyranone, pyranopyranone.

Abstract: A one-pot, three-component reaction of an isatin and kojic acid with an active methylene compound such as ethyl cyanoacetate, methyl cyanoacetate and malononitrile in methanol using catalytic amount of DABCO to give 2'- amino-6'-(hydroxymethyl)-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-2,8'-diones in good to excellent yields under reflux conditions, is described.

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Rahmati Abbas, Khalesi Zahra and Kenarkoohi Tahmineh, Three-Component Synthesis of Spiro[Indoline-3,4'-Pyrano[3,2-b]Pyran]- 2,8'-Diones Using a One-Pot Reaction, Combinatorial Chemistry & High Throughput Screening 2014; 17 (2) . https://dx.doi.org/10.2174/13862073113166660067