Combinatorial Synthesis of Benzimidazole-Azo-Phenol Derivatives as Antifungal Agents

Title:Combinatorial Synthesis of Benzimidazole-Azo-Phenol Derivatives as Antifungal Agents

Volume: 17 Issue: 1

Author(s): Yazhen Ke, Xiaoyan Zhi, Xiang Yu, Guodong Ding, Chun Yang and Hui Xu

Affiliation:

Keywords: Antifungal activity, benzimidazole-azo-phenol, phytopathogenic fungi, synthesis.

Abstract: A chemically diverse library of benzimidazole-azo-phenol derivatives was efficiently prepared and screened for their antifungal activities against five phytopathogenic fungi. Some compounds exhibited potent antifungal activities. As compared with a commercially available agricultural fungicide, hymexazol, especially compound V-5 showed the most promising broad-spectrum antifungal activities against five phytopathogenic fungi. The EC₅₀ values of V-5 against F. graminearum, A. solani, V. mali, B. cinerea, and C. lunata were 0.09, 0.08, 0.06, 0.07, and 0.11 μmol/mL, respectively.

Cite this article as:

Ke Yazhen, Zhi Xiaoyan, Yu Xiang, Ding Guodong, Yang Chun and Xu Hui, Combinatorial Synthesis of Benzimidazole-Azo-Phenol Derivatives as Antifungal Agents, Combinatorial Chemistry & High Throughput Screening 2014; 17 (1) . https://dx.doi.org/10.2174/13862073113166660058