A Review of Cyanoacetyl Indoles (CAIs): Versatile Starting Materials in Organic Synthesis.

Title:A Review of Cyanoacetyl Indoles (CAIs): Versatile Starting Materials in Organic Synthesis.

Volume: 10 Issue: 5

Author(s): Thavendran Govender, Glenn E.M. Maguire, Hendrik G. Kruger and Morteza Shiri

Affiliation:

Keywords: Cyanoacetyl indoles (CAIs), Friedel-Crafts, cyclisation, heterocycles, indoles, pyridines, quinolines.

Abstract: Cyanoacetylindoles (CAIs) are easily obtained from the reaction of indoles and cyanoacetic acid, and are used as versatile starting materials in the synthesis of different heterocycles. This review focuses on the application of CAIs to generate a large diversity of indolyl heterocycles such as pyrazoles, triazoles, pyridines, dihydropyridines, pyrimidines, ozathiols, thiophenes, oxazoles, quinolines and many other complex heterocycles.

Cite this article as:

Govender Thavendran, Maguire E.M. Glenn, Kruger G. Hendrik and Shiri Morteza, A Review of Cyanoacetyl Indoles (CAIs): Versatile Starting Materials in Organic Synthesis., Current Organic Synthesis 2013; 10 (5) . https://dx.doi.org/10.2174/1570179411310050005