Recent Advances in the Use of Cyclodextrins in Antifungal Formulations

Title:Recent Advances in the Use of Cyclodextrins in Antifungal Formulations

Volume: 13 Issue: 21

Author(s): Fliur Macaev, Veaceslav Boldescu, Athina Geronikaki and Natalia Sucman

Affiliation:

Keywords: Antimycotic, cyclodextrins, synergistic effect.

Abstract: Cyclodextrins are usually used in antifungal formulations as auxiliary substances to improve solubility, stability, or other physicochemical properties of the active compound. Nevertheless, more and more research and practical use results indicate that cyclodextrins might also act as active compounds in pharmaceutical formulations. The biological effects of cyclodextrins, important for their use within antimycotic formulations, can be divided into: effects based on the ability of cyclodextrins to form inclusion complexes with endogenous substances (membrane lipids, cellular cholesterol), effects based on formation of inclusion complexes with component parts of fungi cells, and effects based on the chemical nature of cyclodextrins and their derivatives. This review will cover the advances in research of biological activity of cyclodextrins with focus on their properties responsible for their synergistic effect with antimycotic compounds.

Cite this article as:

Macaev Fliur, Boldescu Veaceslav, Geronikaki Athina and Sucman Natalia, Recent Advances in the Use of Cyclodextrins in Antifungal Formulations, Current Topics in Medicinal Chemistry 2013; 13 (21) . https://dx.doi.org/10.2174/15680266113136660194