Modulation of Prion by Small Molecules: From Monovalent to Bivalent and Multivalent Ligands

Title:Modulation of Prion by Small Molecules: From Monovalent to Bivalent and Multivalent Ligands

Volume: 13 Issue: 19

Author(s): Matteo Staderini, Giuseppe Legname, Maria Laura Bolognesi and J. Carlos Menéndez

Affiliation:

Keywords: Prion protein, protein misfolding diseases, neurodegenerative diseases, protein-protein interaction, bifunctional ligands, molecular tweezers, palindromic compounds.

Abstract: Prion diseases are fatal neurodegenerative disorders that affect humans and animals and for which no pharmacological treatment is available. Compounds consisting of two identical moieties joined via an appropriate spacer (i.e. bivalent compounds) have turned out to be effective tools to prevent prion fibril formation and exhibit an improved biological profile with regard to the corresponding monovalent derivatives. In this review we discuss the importance of the bivalent strategy as a viable approach to design new chemical entities to combat prion diseases.

Cite this article as:

Staderini Matteo, Legname Giuseppe, Bolognesi Laura Maria and Menéndez Carlos J., Modulation of Prion by Small Molecules: From Monovalent to Bivalent and Multivalent Ligands, Current Topics in Medicinal Chemistry 2013; 13 (19) . https://dx.doi.org/10.2174/15680266113136660176