Colloidal Carriers for Ophthalmic Drug Delivery

Title: Colloidal Carriers for Ophthalmic Drug Delivery

Volume: 6 Issue: 3

Author(s): Rubiana Mara Mainardes, Maria Cristina Cocenza Urban, Priscila Oliveira Cinto, Najeh Maissar Khalil, Marco Vinicius Chaud, Raul Cesar Evangelista and Maria Palmira Daflon Gremiao

Affiliation:

Keywords: ophthalmic delivery, ocular bioavailability, colloidal drug delivery systems

Abstract: To achieve effective drug concentration at the intended site for a sufficient period of time is a requisite desired for many drug formulations. For drugs intended to ocular delivery, its poor bioavailability is due to pre-corneal factors. Most ocular diseases are treated by topical drug application in the form of solution, suspension and ointment. However, such dosage forms are no longer sufficient to combat some ocular diseases. Intravitreal drug injection is the current therapy for disorders in posterior segment. The procedure is associated with a high risk of complications, particularly when frequent, repeated injections are required. Thus, sustained-release technologies are being proposed, and the benefits of using colloidal carriers in intravitreal injections are currently under investigation for posterior drug delivery. This review will discuss recent progress and specific development issues relating to colloidal drug delivery systems, such as liposomes, niosomes, nanoparticles, and microemulsions in ocular drug delivery.

Cite this article as:

Mainardes Mara Rubiana, Urban Cristina Cocenza Maria, Cinto Oliveira Priscila, Khalil Maissar Najeh, Chaud Vinicius Marco, Evangelista Cesar Raul and Daflon Gremiao Palmira Maria, Colloidal Carriers for Ophthalmic Drug Delivery, Current Drug Targets 2005; 6 (3) . https://dx.doi.org/10.2174/1389450053765914