Design and Synthesis of Novel 2- Substituted Benzothiazole Compounds as PTP1B Inhibitors

Title:Design and Synthesis of Novel 2- Substituted Benzothiazole Compounds as PTP1B Inhibitors

Volume: 11 Issue: 4

Author(s): Arun P. Chandrasekharappa, Sangamesh E. Badiger, Pramod K. Dubey, Sunil K. Panigrahi and Sekhar Reddy VVV. Manukonda

Affiliation:

Keywords: Benzothiazoles, Oxamic acids, PTP1B, Type 2 Diabetes, pTyr mimetics, Disubstituted sulfonamides.

Abstract: Protein tyrosine phosphatase 1B (PTP1B) is a well known drug target for the treatment of type 2 diabetes mellitus (T2DM). Diverse inhibitors have been reported in literature that inhibit PTP1B. We have reported 2-substituted benzoxazole class of In PTP1B inhibitors earlier. Present work describes 2-substituted benzothiazole compounds as PTP1B inhibitor as an extension of our previous study. Compound 23c, a disubstituted para-Bromobenzyl sulfonamide compound, exhibited moderate biochemical potency (Ki) of 1.4 µM. SAR on synthesized compounds was explained using molecular modeling study.

Cite this article as:

Chandrasekharappa P. Arun, Badiger E. Sangamesh, Dubey K. Pramod, Panigrahi K. Sunil and Manukonda Reddy VVV. Sekhar, Design and Synthesis of Novel 2- Substituted Benzothiazole Compounds as PTP1B Inhibitors, Letters in Drug Design & Discovery 2014; 11 (4) . https://dx.doi.org/10.2174/15701808113106660076

DOI https://dx.doi.org/10.2174/15701808113106660076	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X