New Fabrication and Applications of Carbohydrate Arrays

Title:New Fabrication and Applications of Carbohydrate Arrays

Volume: 21 Issue: 3

Author(s): Gangliang Huang, Xin Chen and Feng Xiao

Affiliation:

Keywords: Carbohydrate arrays, carbohydrate-protein interactions, carbohydrate-binding lectins or antibodies, fabrication strategies, applications.

Abstract: Carbohydrate arrays are used as high-throughput screening platforms to study the carbohydrate-mediated recognition events for glycobiology. The polysaccharide arrays are easy to fabricate by non-covalently or covalently immobilizing polysaccharides onto array surfaces because polysaccharides have hydrophobic interactions. Oligosaccharides must be derived and covalently or non-covalently immobilized onto array surfaces to fabricate oligosaccharide arrays because they have hydrophilic interactions. At the moment, carbohydrate arrays are mainly used to study the carbohydrate-protein interactions and carbohydrate-binding lectins or antibodies, which are possible to be applied to clinics and diagnoses. This review mainly summed up the new fabrication strategies of carbohydrate arrays and their applications in recent four years.

Cite this article as:

Huang Gangliang, Chen Xin and Xiao Feng, New Fabrication and Applications of Carbohydrate Arrays, Current Medicinal Chemistry 2014; 21 (3) . https://dx.doi.org/10.2174/09298673113206660267