Benzopyran Derivatives as Cardio-selective ATP-sensitive Potassium Channel Openers: A Review

Title:Benzopyran Derivatives as Cardio-selective ATP-sensitive Potassium Channel Openers: A Review

Volume: 13 Issue: 12

Author(s): Mohsina Bano, Kuldipsinh P. Barot, Shaik Miftah Ahmed, Stoyanka Nikolova, Illiyan Ivanov and Manjunath D. Ghate

Affiliation:

Keywords: ATP-sensitive potassium channels (K_ATP), antihypertensives, antiarrhythmics, benzopyrans, cardio-protectives, smooth muscle relaxation, vasodilators.

Abstract: Benzopyran derivatives are the potassium channel openers (KCOs) having antihypertensive, cardio-protective, myocardial protectors, powerful peripheral vasodilators and anti-ischemic activity. Their usage as anti-ischemic including angina, hypertension and diabetes is thought to be due to the stimulation of K_ATP channels which are contemplated to produce vasorelaxation and myocardial protection. It is observed that potassium channels are involved in mediating the cardio-protective effects of pre-conditioning in animal models and man. KCOs protect heart from an ischemic insult without contribution from vasodilatation. This review provides an overview of the characteristics of KCOs and their actions on subtypes used widely for the treatments of various diseases including hypertension, cardiac ischemia, arrhythmia, smooth muscle relaxation, diabetes, cardio-protective and anti-angiogenic activities.

Cite this article as:

Bano Mohsina, Barot P. Kuldipsinh, Ahmed Miftah Shaik, Nikolova Stoyanka, Ivanov Illiyan and Ghate D. Manjunath, Benzopyran Derivatives as Cardio-selective ATP-sensitive Potassium Channel Openers: A Review, Mini-Reviews in Medicinal Chemistry 2013; 13 (12) . https://dx.doi.org/10.2174/13895575113136660084