Genetics, Structure, Function, Mode of Actions and Role in Cancer Development of CYP17

Title:Genetics, Structure, Function, Mode of Actions and Role in Cancer Development of CYP17

Volume: 14 Issue: 1

Author(s): Tatyana. A Sushko, Andrei A. Gilep and Sergey A. Usanov

Affiliation:

Keywords: Cytochrome P450, CYP17, hormone-dependent cancer, inhibitors of androgen biosynthesis, prostate cancer, steroid hormone biosynthesis, steroid 17α-hydroxylase, 17, 20-lyase.

Abstract: Most prostate and breast cancers are hormone dependent. The inhibition of steroid 17α-hydroxylase/17,20- lyase (CYP17), which is a crucial enzyme for steroid hormone biosynthesis, is widely used to treat androgen-dependent prostate cancer (PC). CYP17 has dual enzymatic activity: 17alpha-hydroxylase activity (utilizing delta4- C21 steroids as substrates) and the 17,20-lyase activity (using delta5- C21 steroids as substrates). The steroid biosynthetic pathway is directed to either the production of corticosteroids or sex hormones depending on the activity of CYP17. In this review, the current information on the genetics, molecular structure, substrate specificity and inhibitors of CYP17 is analyzed and discussed.

Cite this article as:

Sushko A Tatyana., Gilep A. Andrei and Usanov A. Sergey, Genetics, Structure, Function, Mode of Actions and Role in Cancer Development of CYP17, Anti-Cancer Agents in Medicinal Chemistry 2014; 14 (1) . https://dx.doi.org/10.2174/187152061131300330