7,9,12b-Triazabenzo[a]aceanthrylen-8-one, the First Representative of a Novel Pentacyclic Ring System and its Biological Activities

Andreas      Puzik; Franz      Bracher

doi:10.2174/1570178611310080006

Abstract

The first entry to the 7,9,12b-triazabenzo[a]aceanthrylene ring system has been accomplished starting from readily accessible 1-(2-bromoacetyl)-β-carboline via 5-aminocanthin-4-one in four steps. The 8-oxo derivative, which can be considered as an annulated diazaacridone, exhibits significant antimicrobial properties.

Keywords: Canthin-4-one, β-Carboline, Diazaacridone, Skraup synthesis, Phthalimide, Antibacterial activity, Antifungal activity.

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Letters in Organic Chemistry

Title:7,9,12b-Triazabenzo[a]aceanthrylen-8-one, the First Representative of a Novel Pentacyclic Ring System and its Biological Activities

Volume: 10 Issue: 8

Author(s): Andreas Puzik and Franz Bracher

Affiliation:

Keywords: Canthin-4-one, β-Carboline, Diazaacridone, Skraup synthesis, Phthalimide, Antibacterial activity, Antifungal activity.

Abstract: The first entry to the 7,9,12b-triazabenzo[a]aceanthrylene ring system has been accomplished starting from readily accessible 1-(2-bromoacetyl)-β-carboline via 5-aminocanthin-4-one in four steps. The 8-oxo derivative, which can be considered as an annulated diazaacridone, exhibits significant antimicrobial properties.

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Puzik Andreas and Bracher Franz, 7,9,12b-Triazabenzo[a]aceanthrylen-8-one, the First Representative of a Novel Pentacyclic Ring System and its Biological Activities, Letters in Organic Chemistry 2013; 10 (8) . https://dx.doi.org/10.2174/1570178611310080006