Pyrazole Derivatives as Antitumor, Anti-Inflammatory and Antibacterial Agents

Title:Pyrazole Derivatives as Antitumor, Anti-Inflammatory and Antibacterial Agents

Volume: 13 Issue: 13

Author(s): Jia-Jia Liu, Meng-yue Zhao, Xin Zhang, Xin Zhao and Hai-Liang Zhu

Affiliation:

Keywords: Pyrazole derivatives, bioactivity, drug targets.

Abstract: Within the past years, many researches on the synthesis, structure-activity relationships (SAR), antitumor, antiinflammatory and anti-bacterial activities of the pyrazole derivatives have been reported. Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents because of their good inhibitory activity against BRAF^V600E, EGFR, telomerase, ROS Receptor Tyrosine Kinase and Aurora-A kinase. In addition, pyrazole derivatives also show good antiinflammatory and anti-bacterial activities. In this review, the bioactivities of the pyrazole derivatives mentioned above will be summarized in detail. We sincerely hope that increasing knowledge of the SAR and cellular processes underlying the bioactivity of pyrazole derivatives will be beneficial to the rational design of new generation of small molecule drugs.

Cite this article as:

Liu Jia-Jia, Zhao Meng-yue, Zhang Xin, Zhao Xin and Zhu Hai-Liang, Pyrazole Derivatives as Antitumor, Anti-Inflammatory and Antibacterial Agents, Mini-Reviews in Medicinal Chemistry 2013; 13 (13) . https://dx.doi.org/10.2174/13895575113139990078