Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Amicable for Automation

Mitta      Kavitha; Bodugam      Mahipal; Prathama   S.   Mainkar; Srivari      Chandrasekhar

doi:10.2174/1386207311316080009

Abstract

A three-component 3+2 cycloaddition reaction followed by Suzuki coupling reaction was carried out to synthesize a library of compounds using automation (parallel synthesizer). Scaffolds that are unexplored in literature were used for the synthesis of library. The iodo-triazoles formed by 3+2 cycloaddition reaction were coupled with boronic acids to get tri-substituted triazoles.

Keywords: Alkynes, azides, Suzuki reaction, Triazoles, [3+2]-cycloaddition.

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Combinatorial Chemistry & High Throughput Screening

Title:Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Amicable for Automation

Volume: 16 Issue: 8

Author(s): Mitta Kavitha, Bodugam Mahipal, Prathama S. Mainkar and Srivari Chandrasekhar

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Keywords: Alkynes, azides, Suzuki reaction, Triazoles, [3+2]-cycloaddition.

Abstract: A three-component 3+2 cycloaddition reaction followed by Suzuki coupling reaction was carried out to synthesize a library of compounds using automation (parallel synthesizer). Scaffolds that are unexplored in literature were used for the synthesis of library. The iodo-triazoles formed by 3+2 cycloaddition reaction were coupled with boronic acids to get tri-substituted triazoles.

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Kavitha Mitta, Mahipal Bodugam, Mainkar S. Prathama and Chandrasekhar Srivari, Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Amicable for Automation, Combinatorial Chemistry & High Throughput Screening 2013; 16 (8) . https://dx.doi.org/10.2174/1386207311316080009