Functional Role of miR-34 Family in Human Cancer

Title:Functional Role of miR-34 Family in Human Cancer

Volume: 14 Issue: 10

Author(s): Rui Wang, Jia Ma, Qiong Wu, Jun Xia, Lucio Miele, Fazlul H Sarkar and Zhiwei Wang

Affiliation:

Keywords: miR-34, cancer, natural compound, oncogene, therapy, tumor suppressor gene.

Abstract: Recently, microRNAs (miRNAs) including miR-34 family have been found to play a critical role in tumorigenesis through regulating the expression of its target genes, which are involved in many cellular processes such as cell proliferation, survival, apoptosis, migration, invasion and angiogenesis. Thus, this review described the role of miR-34 family and how its deregulation is involved in the development and progression of human malignances. Moreover, we described the potential role of miR-34 as a novel biomarker for tumor diagnosis. Furthermore, we summarized that miR-34 family could be up-regulated by natural compounds in human cancers. Therefore, targeting miR-34 family could be a novel strategy for achieving better treatment outcome of cancer patients in the future.

Cite this article as:

Wang Rui, Ma Jia, Wu Qiong, Xia Jun, Miele Lucio, Sarkar H Fazlul and Wang Zhiwei, Functional Role of miR-34 Family in Human Cancer, Current Drug Targets 2013; 14 (10) . https://dx.doi.org/10.2174/13894501113149990191