A New Multicomponent Protocol for the Synthesis of Pyridines and Fused Pyridines via a Formal aza [3+3] cycloaddition

Giammarco      Tenti; Mª   Teresa   Ramos; Jose   Carlos   Menendez

doi:10.2174/1570179411310040008

Abstract

An efficient method for the synthesis of pyridines related to nicotinic acid and their fused derivatives is described. The overall process involves a sequence comprising a four-component reaction that creates the heterocyclic framework from very simple open-chain precursors and two elimination steps, that are performed without the need for purifying any intermediate.

Keywords: Multicomponent reactions, elimination reactions, heterocyclic synthesis, pyridines, quinolines.

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Current Organic Synthesis

Title:A New Multicomponent Protocol for the Synthesis of Pyridines and Fused Pyridines via a Formal aza [3+3] cycloaddition

Volume: 10 Issue: 4

Author(s): Giammarco Tenti, Mª Teresa Ramos and Jose Carlos Menendez

Affiliation:

Keywords: Multicomponent reactions, elimination reactions, heterocyclic synthesis, pyridines, quinolines.

Abstract: An efficient method for the synthesis of pyridines related to nicotinic acid and their fused derivatives is described. The overall process involves a sequence comprising a four-component reaction that creates the heterocyclic framework from very simple open-chain precursors and two elimination steps, that are performed without the need for purifying any intermediate.

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Tenti Giammarco, Ramos Teresa Mª and Menendez Carlos Jose, A New Multicomponent Protocol for the Synthesis of Pyridines and Fused Pyridines via a Formal aza [3+3] cycloaddition, Current Organic Synthesis 2013; 10 (4) . https://dx.doi.org/10.2174/1570179411310040008