Synthesis and Biological Activity of Nitric Oxide-releasing Derivatives of Ferulic Acid as Potential Agents for the Treatment of Chronic Kidney Diseases

Title:Synthesis and Biological Activity of Nitric Oxide-releasing Derivatives of Ferulic Acid as Potential Agents for the Treatment of Chronic Kidney Diseases

Volume: 9 Issue: 6

Author(s): Hao-Ran Liu, Ying Liu, Yan-Lai Li, Min-You Qi and Wu-Kun Liu

Affiliation:

Keywords: Ferulic Acid, Nitric Oxide Donor; Chronic Kidney Disease, Adenine.

Abstract: In order to search for novel potential agents for the treatment of chronic kidney diseases (CKD), nitric oxide (NO)-releasing derivatives (5a-c) of ferulic acid were synthesized and characterized by MS, 1H NMR, and elementary analysis. They showed different NO-releasing rate in the absence or presence of L-cysteine in vitro. In the adenine induced CKD rats, these compounds revealed reno-protective effect via lowering blood urea nitrogen (BUN), creatinine (Cr) in serum and malondialdehyde (MDA) in kidney, increasing NO and superoxide dismutase (SOD) level in kidney. Among them, 3-methoxy-4-(nitrooxy)ethoxy cinnamic acid (5a) was confirmed to have a higher NO-releasing rate in vitro and better effect in ameliorating adenine-induced kidney damage in rats.

Cite this article as:

Liu Hao-Ran, Liu Ying, Li Yan-Lai, Qi Min-You and Liu Wu-Kun, Synthesis and Biological Activity of Nitric Oxide-releasing Derivatives of Ferulic Acid as Potential Agents for the Treatment of Chronic Kidney Diseases, Medicinal Chemistry 2013; 9 (6) . https://dx.doi.org/10.2174/1573406411309060012