Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

Title:Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

Volume: 16 Issue: 10

Author(s): Zinatossadat Hossaini, Samereh Seyfi, Faramarz Rostami-Charati and Mehdi Ghambarian

Affiliation:

Keywords: Indenoimidazole, Ninhydrine, Primary amines, three-component reaction, trichloroacetonitrile.

Abstract: A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of novel imidazole derivatives. The three-component condensation reactions of primary amines with trichloroacetonitrile in the presence of ninhydrine in water are developed as efficient and clean green synthetic procedures for the high-yielding preparation of imidazoles.

Cite this article as:

Hossaini Zinatossadat, Seyfi Samereh, Rostami-Charati Faramarz and Ghambarian Mehdi, Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water, Combinatorial Chemistry & High Throughput Screening 2013; 16 (10) . https://dx.doi.org/10.2174/13862073113169990046