Synthesis of Unsaturated α-Acyloxybenzothiazoleamides via the Passerini Three-Component Reaction

Fatemeh      Sheikholeslami-Farahani; Ashraf   S.   Shahvelayati

doi:10.2174/13862073113169990041

Abstract

4-Benzothiazol-2-ylamino-4-oxo-2-butenoic acid, prepared from reaction of 2-aminobenzothiazole and maleic anhydride, are used as an acid component in Passerini three-component reaction, under solvent-free media, to produce unsaturated α-benzothiazole acyloxyamides in good yields.

Keywords: 2-Aminobenzothiazole, maleic anhydride, passerini reaction, solvent-free media.

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Combinatorial Chemistry & High Throughput Screening

Title:Synthesis of Unsaturated α-Acyloxybenzothiazoleamides via the Passerini Three-Component Reaction

Volume: 16 Issue: 9

Author(s): Fatemeh Sheikholeslami-Farahani and Ashraf S. Shahvelayati

Affiliation:

Keywords: 2-Aminobenzothiazole, maleic anhydride, passerini reaction, solvent-free media.

Abstract: 4-Benzothiazol-2-ylamino-4-oxo-2-butenoic acid, prepared from reaction of 2-aminobenzothiazole and maleic anhydride, are used as an acid component in Passerini three-component reaction, under solvent-free media, to produce unsaturated α-benzothiazole acyloxyamides in good yields.

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Sheikholeslami-Farahani Fatemeh and Shahvelayati S. Ashraf, Synthesis of Unsaturated α-Acyloxybenzothiazoleamides via the Passerini Three-Component Reaction, Combinatorial Chemistry & High Throughput Screening 2013; 16 (9) . https://dx.doi.org/10.2174/13862073113169990041