MicroRNAs: Biomarkers for Cardiovascular Disease in Patients with Diabetes Mellitus

Title:MicroRNAs: Biomarkers for Cardiovascular Disease in Patients with Diabetes Mellitus

Volume: 13 Issue: 13

Author(s): Alexandros Briasoulis, Dimitris Tousoulis, Georgia Vogiatzi, Gerasimos Siasos, Nikos Papageorgiou, Evangelos Oikonomou, Vasiliki Genimata, Theodosia Konsola and Christodoulos Stefanadis

Affiliation:

Keywords: miRNAS, diabetes mellitus, cardiovascular disease.

Abstract: Diabetes mellitus (DM) is a complex metabolic disorder characterized by low insulin production/secretion by pancreatic beta cells and/or low responsiveness by insulin target tissues MicroRNAs have been associated with DM, but it is not clear whether this is a cause or an effect of metabolic abnormalities related to DM. In the hyperglycemic environment miRNAs are in involved in multiple stages of cardiovascular disease development and progression. In diabetic patients with cardiovascular disease miRNAs could potentially serve as early biomarkers for diagnosis and as therapeutic agents. The current review focuses on the involvement of miRNAs in molecular mechanisms underlying the pathogenesis of DM and its cardiovascular complications.

Cite this article as:

Briasoulis Alexandros, Tousoulis Dimitris, Vogiatzi Georgia, Siasos Gerasimos, Papageorgiou Nikos, Oikonomou Evangelos, Genimata Vasiliki, Konsola Theodosia and Stefanadis Christodoulos, MicroRNAs: Biomarkers for Cardiovascular Disease in Patients with Diabetes Mellitus, Current Topics in Medicinal Chemistry 2013; 13 (13) . https://dx.doi.org/10.2174/15680266113139990102