A Novel Three-Component Reaction for the Synthesis of 1,3-Benzoxazines in Water

Faramarz      Rostami-Charati

doi:10.2174/1386207311301010009

Abstract

A simple and proficient method for the synthesis of 1,3-benzoxazine derivatives via three-component reaction of isocyanide and isoquinoline with 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone or 4-hydroxycumarine in water in the presence of piperidine at 70°C is reported.

Keywords: 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, 1, 3-benzoxazine, Isocyanide, isoquinoline, threecomponent reaction.

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Combinatorial Chemistry & High Throughput Screening

Title:A Novel Three-Component Reaction for the Synthesis of 1,3-Benzoxazines in Water

Volume: 16 Issue: 10

Author(s): Faramarz Rostami-Charati

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Keywords: 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, 1, 3-benzoxazine, Isocyanide, isoquinoline, threecomponent reaction.

Abstract: A simple and proficient method for the synthesis of 1,3-benzoxazine derivatives via three-component reaction of isocyanide and isoquinoline with 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone or 4-hydroxycumarine in water in the presence of piperidine at 70°C is reported.

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Rostami-Charati Faramarz, A Novel Three-Component Reaction for the Synthesis of 1,3-Benzoxazines in Water, Combinatorial Chemistry & High Throughput Screening 2013; 16 (10) . https://dx.doi.org/10.2174/1386207311301010009