Ageing as a Trait de Union Between Diabetes and Dementia for Frailty

Title:Ageing as a Trait de Union Between Diabetes and Dementia for Frailty

Volume: 12 Issue: 4

Author(s): Roberta Semprini, Mauro Ragonese, Maurizio Poggi, Antonella Franze and Alessandro Martorana

Affiliation:

Keywords: Alzheimer’s disease, diabetes mellitus type 2, insulin, amyloid β-peptide42, tau.

Abstract: A frail patient is one who carries a sum of poly-pathologies, whose co-existence may shorten his life expectation. Diabetes mellitus type 2 and metabolic syndrome play a substantial role in it, but dementia has increasingly risen in importance. Interestingly, the insulin pathway was suggested to be responsible for the metabolic cascade that leads to amyloid-beta deposit and pathology. Nevertheless, a clear relationship between them was just experimentally, rather than clinically demonstrated. In this work the authors suggest a possible link between insulin, diabetes and Alzheimer’s disease, whose co-existence could be responsible for physical and cognitive decline but not for frailty. We suggest that these factors could be responsible for frailty only if senescence-associated.

Cite this article as:

Semprini Roberta, Ragonese Mauro, Poggi Maurizio, Franze Antonella and Martorana Alessandro, Ageing as a Trait de Union Between Diabetes and Dementia for Frailty, CNS & Neurological Disorders - Drug Targets 2013; 12 (4) . https://dx.doi.org/10.2174/1871527311312040012