One-Pot Synthesis of Novel Spiro[quinazoline/pyrimidine]ones via Multi Component Reaction

Title:One-Pot Synthesis of Novel Spiro[quinazoline/pyrimidine]ones via Multi Component Reaction

Volume: 10 Issue: 6

Author(s): Gangadhar Meshram, Pramod Wagh, Shruti Deshpande and Vipul Amratlal

Affiliation:

Keywords: Acenaphthylene-1, 2-dione, 1, 3-Dicarbonyls, dihydropyrimidinone, isatin, multi-component reaction, ninhydrin, spiroheterocycles.

Abstract: A new and facile one-pot synthesis of the biologically important spiro[quinazoline/pyrimidine]ones scaffold was synthesized simply by the reaction of isatin, 1,3-dione and urea or thiourea. The scope of the reaction was successfully extended by employing two other reactive ketones (acenaphthylene-1,2-dione and ninhydrin) instead of isatin. A series of new spiro cyclic derivatives via multi-component reaction was obtained by using guanidine and employing different 1,3 - dicarbonyl compounds.

Cite this article as:

Meshram Gangadhar, Wagh Pramod, Deshpande Shruti and Amratlal Vipul, One-Pot Synthesis of Novel Spiro[quinazoline/pyrimidine]ones via Multi Component Reaction, Letters in Organic Chemistry 2013; 10 (6) . https://dx.doi.org/10.2174/1570178611310060006