Abstract
Renal allograft thrombosis is the leading cause of graft failure in pediatric transplant recipients in the early post-transplant period. Various factors at multiple levels- donor, recipient, surgical and therapy-related, come into play in contributing to this risk. While early detection and intervention are keys in limiting the adverse effect of graft thrombosis on graft survival, preventative strategies have the most to offer in reducing morbidity related to this devastating complication. This article reviews the epidemiology, risk factors, diagnostic and therapeutic modalities to assist the clinician in taking care of children who are in the process of receiving renal transplants. The authors also address various strategies to screen for and prevent thromboses in this population. Lastly, we identify gaps in our knowledge base related to allograft thrombosis, to bridge which, robust research is urgently needed.
Keywords: Pediatric, complications, kidney, renal transplants, thrombosis, vascular.
Current Pediatric Reviews
Title:Renal Allograft Thrombosis
Volume: 9 Issue: 3
Author(s): Gia Oh and Lavjay Butani
Affiliation:
Keywords: Pediatric, complications, kidney, renal transplants, thrombosis, vascular.
Abstract: Renal allograft thrombosis is the leading cause of graft failure in pediatric transplant recipients in the early post-transplant period. Various factors at multiple levels- donor, recipient, surgical and therapy-related, come into play in contributing to this risk. While early detection and intervention are keys in limiting the adverse effect of graft thrombosis on graft survival, preventative strategies have the most to offer in reducing morbidity related to this devastating complication. This article reviews the epidemiology, risk factors, diagnostic and therapeutic modalities to assist the clinician in taking care of children who are in the process of receiving renal transplants. The authors also address various strategies to screen for and prevent thromboses in this population. Lastly, we identify gaps in our knowledge base related to allograft thrombosis, to bridge which, robust research is urgently needed.
Export Options
About this article
Cite this article as:
Oh Gia and Butani Lavjay, Renal Allograft Thrombosis, Current Pediatric Reviews 2013; 9 (3) . https://dx.doi.org/10.2174/1573396311309030006
DOI https://dx.doi.org/10.2174/1573396311309030006 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Progress in the Development of Adenosine Receptor Ligands as Antiinflammatory Drugs
Current Topics in Medicinal Chemistry Pharmacotherapy of Dilated Cardiomyopathy
Current Pharmaceutical Design Simultaneous Determination of Cytochrome P450 Oxidation Capacity in Humans: A Review on the Phenotyping Cocktail Approach
Current Pharmaceutical Biotechnology Urocortin: Cardiovascular Actions and Therapeutic Implications
Letters in Drug Design & Discovery Third Generation Radiopharmaceuticals for Imaging and Targeted Therapy
Current Pharmaceutical Analysis Adenosine in the Inflamed Gut: A Janus Faced Compound
Current Medicinal Chemistry Nitric Oxide and Dietary Factors: Part III Minerals, Vitamins and Other Dietary and Lifestyle Factors
Vascular Disease Prevention (Discontinued) Data-driven Approach to Detect and Predict Adverse Drug Reactions
Current Pharmaceutical Design Phosphodiesterase Inhibition as a Therapeutic Target for Brain Ischemia
CNS & Neurological Disorders - Drug Targets Microbial Efflux Pump Inhibition: Tactics and Strategies
Current Pharmaceutical Design Current Developments in the Synthesis and Biological Activity of Aza-C-Nucleosides:Immucillins and Related Compounds
Current Medicinal Chemistry Serotonin-2 Receptor Agonists as Novel Ocular Hypotensive Agents and their Cellular and Molecular Mechanisms of Action: Novel Drug Targets for Glaucoma Treatment
Current Drug Targets Endocannabinoids and their Involvement in the Neurovascular System
Current Neurovascular Research HIF Prolyl 4-Hydroxylases and their Potential as Drug Targets
Current Pharmaceutical Design Renal Complications of Fabry Disease
Current Pharmaceutical Design Anesthetic Neuroprotection: Antecedents and An Appraisal of Preclinical and Clinical Data Quality
Current Pharmaceutical Design Pulmonary Hypertension in the Critically Ill
Current Hypertension Reviews Small Molecules in Treatment of Sepsis
Current Drug Targets The Plasma and Tissue Kininogen-kallikrein-kinin System: Role in the Cardiovascular System
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Clonidine in Perioperative Medicine and Intensive Care Unit: More Than An Anti-Hypertensive Drug
Current Drug Targets