Chemokine Contribution in Stem Cell Engraftment into the Infarcted Myocardium

Elisa A.      Liehn; Eugen      Radu; Alexander      Schuh

doi:10.2174/1574888X11308040003

Abstract

Modern life styles have made cardiovascular disease the leading cause of morbidity and mortality worldwide. Although current treatments substantially ameliorate patients’ prognosis after MI, they cannot restore the affected tissue or entirely re-establish organ function. Therefore, the main goal of modern cardiology should be to design strategies to reduce myocardial necrosis and optimize cardiac repair following MI. Cell-based therapy was considered a novel and potentially new strategy in regenerative medicine; however, its clinical implementation has not yielded the expected results. Chemokines seem to increase the efficiency of cell-therapy and may represent a reliable method to be exploited in the future. This review surveys current knowledge of cell therapy and highlights key insights into the role of chemokines in stem cell engraftment in infarcted myocardium and their possible clinical implications.

Keywords: Cell transplantation, chemokine, inflammation, myocardial infarction, remodeling.

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