Abstract
The practical synthesis of 3-(trifluoromethyl)-triazolopiperazine the key intermediate of Sitagliptin and 3- (trifluoromethyl)-triazolopyridine was carried out employing industrially feasible transformations. The other advantage of this method is the new environment friendly approach to synthesize triazolopiperazine and triazolopyridines by eliminating the commonly used trifluoroacetic anhydride and polyphosphoric acid.
Keywords: Sitagliptin, 3-(trifluoromethyl)-triazolopiperazine, 3-(trifluoromethyl)-triazolopyridine, antidiabetic.
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