Catalyst-free Synthesis of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine Derivatives by Aza-Diels-Alder Reaction

Title:Catalyst-free Synthesis of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine Derivatives by Aza-Diels-Alder Reaction

Volume: 10 Issue: 5

Author(s): Jairo Quiroga, Angela Valencia, Alfredo Perez, Jaime Galvez, Rodrigo Abonia and Braulio Insuasty

Affiliation:

Keywords: Aminopyrazoles, DMF-DMA, TMOF, maleimides, pyrazolopyrrolopyridines, Aza-Diels-Alder reaction.

Abstract: A series of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives was synthesized via catalyst-free bi-component and one-pot reactions of 5-aminopyrazoles, DMF-DMA (or TMOF) and N-arylmaleimides in xylene as solvent. This protocol showed advantages of milder reaction conditions, easier work-up, shorter reaction times and good yields, over other approaches tested.

Cite this article as:

Quiroga Jairo, Valencia Angela, Perez Alfredo, Galvez Jaime, Abonia Rodrigo and Insuasty Braulio, Catalyst-free Synthesis of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine Derivatives by Aza-Diels-Alder Reaction, Letters in Organic Chemistry 2013; 10 (5) . https://dx.doi.org/10.2174/1570178611310050006