Weakly Stable Regions and Protein-Protein Interactions in Beta-Barrel Membrane Proteins

Title:Weakly Stable Regions and Protein-Protein Interactions in Beta-Barrel Membrane Proteins

Volume: 20 Issue: 8

Author(s): Hammad Naveed and Jie Liang

Affiliation:

Keywords: β-barrel membrane proteins — protein-protein interaction — weakly stable regions— VDAC — Tom40— OmpF.

Abstract: We briefly discuss recent progress in computational characterization of the sequence and structural properties of β-barrel membrane properties. We discuss the emerging concept of weakly stable regions in β-barrel membrane proteins, computational methods to identify these regions and mechanisms adopted by β-barrel membrane proteins in nature to stabilize them. We further discuss computational methods to identify protein-protein interactions in β-barrel membrane proteins and recent experimental studies that aim at altering the biophysical properties including oligomerization state and stability of β-barrel membrane proteins based on the emerging organization principles of these proteins from recent computational studies.

Cite this article as:

Naveed Hammad and Liang Jie, Weakly Stable Regions and Protein-Protein Interactions in Beta-Barrel Membrane Proteins, Current Pharmaceutical Design 2014; 20 (8) . https://dx.doi.org/10.2174/13816128113199990071