Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity†

Title:Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity†

Volume: 10 Issue: 3

Author(s): Irem Kulu, Asli Kopruceli, Gokce Goksu and Nuket Ocal

Affiliation:

Keywords: Antidepressant drugs, bicyclic imides, biological activity, C-C coupling, isoxazolines, palladium(II) acetate, arylpiperazine moiety.

Abstract: The C-C coupling of bicyclic alkene 4 with aryl and heteroaryl iodides gave under reductive Heck conditions the Caryl( hetaryl), N-[((4-pyrimidin-2-yl)piperazin-1-yl)butyl]substituted bicyclic imides 5a-f. The [3+2] cycloadditions of 4 with various nitrile oxides yielded the bridged isoxazoline derivatives 6-8 with potential biological activity.

Cite this article as:

Kulu Irem, Kopruceli Asli, Goksu Gokce and Ocal Nuket, Synthesis of New Aryl(Hetaryl)-Substituted Tandospirones Under Reductive Heck Type Hydroarylations and Isoxazoline Derivatives via 1,3-Dipolar Cycloaddition Reactions with Expected Anxiolytic Activity†, Current Organic Synthesis 2013; 10 (3) . https://dx.doi.org/10.2174/1570179411310030010