First Enantioselective Organocatalytic Addition of Nitromethylphenylsulfone to Enals. Enantioselective Synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters

Ramon      Rios; SimonaHybelbauerova; Ivana      Csarova; Jan      Vesely

doi:10.2174/1570179411310030008

Abstract

A highly enantioselectiveorganocatalyticnitromethylphenylsulfone addition to aliphatic α,β-unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the cyclic compounds in moderate yields, good diastereoselectivities and excellent enantioselectivities.

Keywords: Cascade reaction, enantioselective, organocatalysis, asymmetric synthesis, secondary amine, cyclization.

« Previous Next »

Rights & Permissions Print Cite

Current Organic Synthesis

Title:First Enantioselective Organocatalytic Addition of Nitromethylphenylsulfone to Enals. Enantioselective Synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters

Volume: 10 Issue: 3

Author(s): Ramon Rios, SimonaHybelbauerova, Ivana Csarova and Jan Vesely

Affiliation:

Keywords: Cascade reaction, enantioselective, organocatalysis, asymmetric synthesis, secondary amine, cyclization.

Abstract: A highly enantioselectiveorganocatalyticnitromethylphenylsulfone addition to aliphatic α,β-unsaturated aldehydes is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the cyclic compounds in moderate yields, good diastereoselectivities and excellent enantioselectivities.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Rios Ramon, SimonaHybelbauerova , Csarova Ivana and Vesely Jan, First Enantioselective Organocatalytic Addition of Nitromethylphenylsulfone to Enals. Enantioselective Synthesis of Cyclohexenones Bearing 3 Contiguousstereogeniccenters, Current Organic Synthesis 2013; 10 (3) . https://dx.doi.org/10.2174/1570179411310030008