Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents

Ravindra   K.   Rawal; V.   R.   Solomon; Yenamandra   S.   Prabhakar; S.   B.   Katti; E.      De Clercq

doi:10.2174/1386207054546496

Abstract

selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204μM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in rationalizing the activity.

Keywords: thiazolidinones, metathiazanones, anti-hiv agents, nnrtis, dicyclohexylcarbodiimide (dcc)

« Previous Next »

Rights & Permissions Print Cite

Combinatorial Chemistry & High Throughput Screening

Title: Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents

Volume: 8 Issue: 5

Author(s): Ravindra K. Rawal, V. R. Solomon, Yenamandra S. Prabhakar, S. B. Katti and E. De Clercq

Affiliation:

Keywords: thiazolidinones, metathiazanones, anti-hiv agents, nnrtis, dicyclohexylcarbodiimide (dcc)

Abstract: selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204μM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in rationalizing the activity.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Rawal K. Ravindra, Solomon R. V., Prabhakar S. Yenamandra, Katti B. S. and De Clercq E., Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents, Combinatorial Chemistry & High Throughput Screening 2005; 8 (5) . https://dx.doi.org/10.2174/1386207054546496