4-Aminoquinazoline Analogs: A Novel Class of Anticancer Agents

Title:4-Aminoquinazoline Analogs: A Novel Class of Anticancer Agents

Volume: 13 Issue: 8

Author(s): Kalpana Singh, P.P. Sharma, A. Kumar, Anurag Chaudhary and R.K. Roy

Affiliation:

Keywords: 4-Aminoquinazoline, antitumor, apoptosis, cytotoxic, epidermal growth factor receptor, tyrosine kinase.

Abstract: 4-Aminoquinazoline analogs have been identified as a new class of cancer chemotherapeutic agents with significant therapeutic efficacy against solid tumors. They are potent and highly selective inhibitors of tyrosine kinase (TK) and epidermal growth factor receptor (EGFR). Till date various 4-aminoquinazoline analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized 4-aminoquinazoline analogs.

Cite this article as:

Singh Kalpana, Sharma P.P., Kumar A., Chaudhary Anurag and Roy R.K., 4-Aminoquinazoline Analogs: A Novel Class of Anticancer Agents, Mini-Reviews in Medicinal Chemistry 2013; 13 (8) . https://dx.doi.org/10.2174/1389557511313080006