Derivatives as 5HT1A Receptor Ligands-Past and Present

Title: Derivatives as 5HT1A Receptor Ligands-Past and Present

Volume: 12 Issue: 15

Author(s): G. Caliendo, V. Santagada, E. Perissutti and F. Fiorino

Affiliation:

Keywords: serotonin, neurotransmitter, g protein-coupled receptors, median raphe nucleus (mrn), ohdpat, enantioselectivity, indolylalkylamines, ergolines, aporphines, qsar

Abstract: Serotonin is a neuromediator, well-know for its implication in mood regulation, anxiety, depression and, insomnia as well as in normal human function such as sleep, sexual activity and appetite. In this way, serotonin (5-hydroxytryptamine, 5-HT) is one of the most attractive targets for medicinal chemists and pharmaceutical companies. Among 5-HTRs, the 5-HT1A subtype is the best studied, and it is generally accepted that it is involved in psychiatric disorders such as anxiety and depression. Several structurally different compounds are known to bind 5-HT1A receptor sites such as aminotetralins, ergolines, arylpiperazines, indolylalkylamines, aporphines and aryloxyalkyl-amines.

Cite this article as:

Caliendo G., Santagada V., Perissutti E. and Fiorino F., Derivatives as 5HT1A Receptor Ligands-Past and Present, Current Medicinal Chemistry 2005; 12 (15) . https://dx.doi.org/10.2174/0929867054367220