Dissecting Bortezomib: Development, Application, Adverse Effects and Future Direction

Title:Dissecting Bortezomib: Development, Application, Adverse Effects and Future Direction

Volume: 19 Issue: 18

Author(s): Biyin Cao, Jie Li and Xinliang Mao

Affiliation:

Keywords: Proteasome inhibitor, bortezomib, adverse effect, resistance.

Abstract: Bortezomib is the first-in-class proteasome inhibitor which has been used worldwide for the treatment of multiple myeloma and mantle cell lymphoma. Bortezomib is under evaluation as a single agent or in combination with other drugs for solid cancers and stem cell transplantation in clinical settings. However, adverse effects and drug resistance have been observed in patients, which is now emerging as a great challenge for the extended application of bortezomib. In this review, we will comprehensively discuss the development of bortezomib, the mechanism underlying its therapeutics, adverse effects and resistance. Second generation of bortezomib and its future directions will also be discussed.

Cite this article as:

Cao Biyin, Li Jie and Mao Xinliang, Dissecting Bortezomib: Development, Application, Adverse Effects and Future Direction, Current Pharmaceutical Design 2013; 19 (18) . https://dx.doi.org/ 10.2174/13816128113199990338