Abstract
Lysophospholipids (LPLs) are secreted physiologically by various cell types. They exhibit a broad range of biological activities, playing highly important roles in the development, activation and regulation of the immune system and are also related to cancerous cells proliferation. Consequently LPLs or their receptors have become attractive targets for developing drugs specially in the treatment of cancers. Then the development of new synthetic methods for the preparation of LPLs is a challenging problem because the elucidation of the mechanistic details involved in the enzymological, cell-biological and membrane–biophysical roles of LPLs relies obviously on the availability of structurally diverse compounds. We will focus our attention on the chemical and enzymatic synthesis of LPLs and on the biological activity in particular of three LPLs, namely 2-lysophosphatidylcholine (2–LPC), lysophosphatidic acid (LPA) and sphingosine– 1–phosphate (S1P).
Keywords: Lysophospholipids, lysophosphatidylcholine, lysophosphatidic acid, sphingosine–1–phosphate, second messenger.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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