Abstract
A simple, convenient and efficient three-component coupling (TCC) reaction toward a variety of (E)-2,3'-bi(3H-indol)-3-one oxime derivatives has been developed. This transformation proceeds via an iron (III)-catalyzed tandem coupling reaction between indoles and sodium nitrite. This methodology provides an alternative approach for easy access of (E)-2,3'-bi(3H-indol)-3-one oximes in good to excellent yields at room temperature.
Keywords: Indoles, iron (III) trichloride, biindoles, tandem reactions, three-component coupling reaction.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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