A Mild and Green Method for the N-BOC Protection of Amines without Assistant of Catalyst Under Solvent-free Conditions

Mohammad      Majid Mojtahedi; Nina      Niknejad; Hojat      Veisi

doi:10.2174/1570178611310020010

Abstract

A facile, green and versatile method for the Boc protection of amines has been developed by a treatment with (Boc)₂O without any additive at room temperature. The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines. The advantages of this method are green, simplicity, short reaction times and excellent yields.

Keywords: N-BOC protection, green, catalyst-free, solvent-free

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Letters in Organic Chemistry

Title:A Mild and Green Method for the N-BOC Protection of Amines without Assistant of Catalyst Under Solvent-free Conditions

Volume: 10 Issue: 2

Author(s): Mohammad Majid Mojtahedi, Nina Niknejad and Hojat Veisi

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Keywords: N-BOC protection, green, catalyst-free, solvent-free

Abstract: A facile, green and versatile method for the Boc protection of amines has been developed by a treatment with (Boc)₂O without any additive at room temperature. The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines. The advantages of this method are green, simplicity, short reaction times and excellent yields.

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Majid Mojtahedi Mohammad, Niknejad Nina and Veisi Hojat, A Mild and Green Method for the N-BOC Protection of Amines without Assistant of Catalyst Under Solvent-free Conditions, Letters in Organic Chemistry 2013; 10 (2) . https://dx.doi.org/10.2174/1570178611310020010