Transient Receptor Potential Channels and Dermatological Disorders

Title:Transient Receptor Potential Channels and Dermatological Disorders

Volume: 13 Issue: 3

Author(s): Rodrigo Valdes-Rodriguez, Shivani B. Kaushik and Gil Yosipovitch

Affiliation:

Keywords: TRPV, TRPA, TRPM, TRPC, TRPML, Itch, skin barrier, hair growth, skin cancers

Abstract: Transient receptor potential (TRP) cation channels are an emerging field of research in dermatology. Beyond their classical role in skin sensory perception, TRPs are involved in various cutaneous functions that include keratinocyte differentiation, apoptosis and melanocyte pigmentation. In addition, they have a role as pharmacological targets in many inflammatory skin diseases including psoriasis, chronic itch, hair disorders and skin cancers. Moreover, mutations in TRPs have recently been related to rare skin conditions such as Olmsted syndrome. This review will cover the role of TRPs in dermatologic conditions with special emphasis on itch and skin inflammatory diseases.

Cite this article as:

Valdes-Rodriguez Rodrigo, B. Kaushik Shivani and Yosipovitch Gil, Transient Receptor Potential Channels and Dermatological Disorders, Current Topics in Medicinal Chemistry 2013; 13 (3) . https://dx.doi.org/10.2174/15680266112129990090