Insight into the Medicinal Chemistry of the Endocannabinoid Hydrolase Inhibitors

C.N.      Kapanda; J.H.      Poupaert; D.M.      Lambert

doi:10.2174/09298673113209990108

Abstract

Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.

Keywords: Endocannabinoid hydrolases, inhibitors, design, chemical structures, inhibition mechanism, structure-activity relationships.

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Current Medicinal Chemistry

Title:Insight into the Medicinal Chemistry of the Endocannabinoid Hydrolase Inhibitors

Volume: 20 Issue: 14

Author(s): C.N. Kapanda, J.H. Poupaert and D.M. Lambert

Affiliation:

Keywords: Endocannabinoid hydrolases, inhibitors, design, chemical structures, inhibition mechanism, structure-activity relationships.

Abstract: Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.

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Kapanda C.N., Poupaert J.H. and Lambert D.M., Insight into the Medicinal Chemistry of the Endocannabinoid Hydrolase Inhibitors, Current Medicinal Chemistry 2013; 20 (14) . https://dx.doi.org/10.2174/09298673113209990108