MicroRNAs and the Heart: Small Things Do Matter

Title:MicroRNAs and the Heart: Small Things Do Matter

Volume: 13 Issue: 2

Author(s): Nikolaos Papoutsidakis, Spyridon Deftereos, Andreas Kaoukis, Georgios Bouras, Georgios Giannopoulos, Andreas Theodorakis, Christos Angelidis, Georgios Hatzis and Christodoulos Stefanadis

Affiliation:

Keywords: Biomarker, cardiovascular, gene, heart failure, microRNA, myocardial infarction

Abstract: MicroRNAs are small RNA molecules and constitute a relatively novel class of gene expression regulators, found in the great majority of eukaryotic cells. Their role in human physiology and pathology is actively being researched with new exciting discoveries continuously coming to the forefront. MicroRNAs play a crucial role in the biogenesis and function of the cardiovascular system and act as important regulators of various metabolic and signaling pathways in cardiovascular disease. In this review there will be a summary on current knowledge about the expression, regulation and function of microRNAs in the most common diseases of the cardiovascular system as well as a presentation of and discussion about their promising future role as new biomarkers and therapeutic targets.

Cite this article as:

Papoutsidakis Nikolaos, Deftereos Spyridon, Kaoukis Andreas, Bouras Georgios, Giannopoulos Georgios, Theodorakis Andreas, Angelidis Christos, Hatzis Georgios and Stefanadis Christodoulos, MicroRNAs and the Heart: Small Things Do Matter, Current Topics in Medicinal Chemistry 2013; 13 (2) . https://dx.doi.org/10.2174/1568026611313020009