Synthesis of Six-membered Azaheterocycles by Means of the β-lactam Synthon Method

Karen      Mollet; Matthias      D’hooghe; Norbert      De Kimpe

doi:10.2174/1570193X11310010001

Abstract

Azaheterocycles comprise relevant target structures within organic chemistry due to the broad diversity of biological activities associated with these scaffolds. In this review, the most important recent procedures for the preparation of functionalized six-membered azaheterocyclic compounds by ring transformation of β-lactams are summarized and discussed.

Keywords: β-lactams, ring transformation, six-membered azaheterocycles, morpholines, piperidines, oxazinanes, piperazines

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Mini-Reviews in Organic Chemistry

Title:Synthesis of Six-membered Azaheterocycles by Means of the β-lactam Synthon Method

Volume: 10 Issue: 1

Author(s): Karen Mollet, Matthias D’hooghe and Norbert De Kimpe

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Keywords: β-lactams, ring transformation, six-membered azaheterocycles, morpholines, piperidines, oxazinanes, piperazines

Abstract: Azaheterocycles comprise relevant target structures within organic chemistry due to the broad diversity of biological activities associated with these scaffolds. In this review, the most important recent procedures for the preparation of functionalized six-membered azaheterocyclic compounds by ring transformation of β-lactams are summarized and discussed.

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Mollet Karen, D’hooghe Matthias and De Kimpe Norbert, Synthesis of Six-membered Azaheterocycles by Means of the β-lactam Synthon Method, Mini-Reviews in Organic Chemistry 2013; 10 (1) . https://dx.doi.org/10.2174/1570193X11310010001