5-Lipoxygenase, Leukotrienes Biosynthesis and Potential Antileukotrienic Agents

Title: 5-Lipoxygenase, Leukotrienes Biosynthesis and Potential Antileukotrienic Agents

Volume: 13 Issue: 2

Author(s): Josef Jampilek, Martin Dolezal, Veronika Opletalova and Jiri Hartl

Affiliation:

Keywords: 5-lipoxygenase, FLAP, LTA4-hydrolase, leukotrienes, antileukotrienic agents

Abstract: Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.

Cite this article as:

Jampilek Josef, Dolezal Martin, Opletalova Veronika and Hartl Jiri, 5-Lipoxygenase, Leukotrienes Biosynthesis and Potential Antileukotrienic Agents, Current Medicinal Chemistry 2006; 13 (2) . https://dx.doi.org/10.2174/092986706775197935