Understanding Apoptosis in Terms of QSAR

Title: Understanding Apoptosis in Terms of QSAR

Volume: 6 Issue: 1

Author(s): Rajeshwar P. Verma

Affiliation:

Keywords: Apoptosis, hydrophobicity, molar refractivity, molar volume, quantitative structure-activity relationship (QSAR)

Abstract: Apoptosis is a cellular mechanism by which unwanted, defective, or damaged cells are rapidly and selectively eliminated to maintain healthy tissue homeostasis in multi-cellular organisms. In this review, we have developed nineteen quantitative structure-activity relationships (QSAR) for different series of compounds with respect to their apoptotic activities against five different cancer cell lines that are T47D, ZR75-1, DLD-1, H1299, and HL60 in order to understand chemical-biological interactions.

Cite this article as:

Verma P. Rajeshwar, Understanding Apoptosis in Terms of QSAR, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (1) . https://dx.doi.org/10.2174/187152006774755528