Abstract
Using a standard two-stage fermentation technique, the fungus Beauveria bassiana (ATCC 7159) was found to convert the eudesmanolide vulgarin (1) to 1α,4α-dihydroxy-5αH,6,11βH-eudesman-6,12-olide (2). The use of the yeast Hansenula anomala ATCC 20170 instead, produced the less polar 4α-hydroxy-1-oxo-5αH,6,11βH-eudesman-6,12-olide (3), in addition to the more polar 3α,4α-dihydroxy-1-oxo-5αH,6,11βH-eudesman-6,12-olide (4). These metabolites were characterized on the basis of their spectral data and the identity of 4 was further confirmed by chemical synthesis.
Keywords: Vulgarin, Biotransformation, 1-epi-tetrahydrovulgarin, dihydrovulgarin, 3α-hydroxydihydrovulgarin
Mini-Reviews in Medicinal Chemistry
Title:Biotransformation of Vulgarin
Volume: 13 Issue: 5
Author(s): Khaled Y. Orabi, Farouk S. El-Feraly, Waleed A. Al-Sulmy and Mohammed A. Al-Yahya
Affiliation:
Keywords: Vulgarin, Biotransformation, 1-epi-tetrahydrovulgarin, dihydrovulgarin, 3α-hydroxydihydrovulgarin
Abstract: Using a standard two-stage fermentation technique, the fungus Beauveria bassiana (ATCC 7159) was found to convert the eudesmanolide vulgarin (1) to 1α,4α-dihydroxy-5αH,6,11βH-eudesman-6,12-olide (2). The use of the yeast Hansenula anomala ATCC 20170 instead, produced the less polar 4α-hydroxy-1-oxo-5αH,6,11βH-eudesman-6,12-olide (3), in addition to the more polar 3α,4α-dihydroxy-1-oxo-5αH,6,11βH-eudesman-6,12-olide (4). These metabolites were characterized on the basis of their spectral data and the identity of 4 was further confirmed by chemical synthesis.
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Cite this article as:
Y. Orabi Khaled, S. El-Feraly Farouk, A. Al-Sulmy Waleed and A. Al-Yahya Mohammed, Biotransformation of Vulgarin, Mini-Reviews in Medicinal Chemistry 2013; 13 (5) . https://dx.doi.org/10.2174/1389557511313050013
DOI https://dx.doi.org/10.2174/1389557511313050013 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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